The Spurs were beaten by 38 points on Thursday night, with the Clippers outscoring the Spurs 138-100.
Paul George led the Clippers with 35 points. Kawhi Leonard added 27 points in the win.
The Spurs were led by Keldon Johnson with 19 points. Isaiah Roby had 14 points, Keita Bates-Diop had 13 points, Doug McDermott had 11 points and Jakob Poeltl added 10 points.
The Spurs are back in action on Saturday night against the Suns.