The Astros will begin their 60-game schedule on July 24th with four home games against the Mariners. The defending American League champs will conclude the Minute Maid Park opening homestand with two games against the Dodgers, who they beat in the 2017 World Series. Houston will play at Dodger Stadium on September 12th-and-13th. The Astros will finish the season with a seven-game trip to Seattle and Texas ending September 27th at the Rangers brand-new Globe Life Park.